As you head southwest on Rt. 340 from Frederick, you’ll find the small town of Knoxville, MD located just prior to crossing the Potomac River into West Virginia. This small, sleepy town offers locals a quiet and rural lifestyle where they can enjoy the peaceful surroundings. The main planned community in the area is Galyn Manor. Outdoor enthusiasts will enjoy hiking and biking along the Appalachian Trail and the C&O Canal. River wanderers, in addition, will relish in the fact that the Potomac River is nearby making it ideal for fishing, kayaking and other water sports.